Akdeniz Üniversitesi

1-Reiter Z,Ozes ON, Tomson S ,Blatt LM, and Taylor MW. 1991. A dual anti-tumor effect of a combination of interferon alpha and 5-fluorouracil or 2-chlorodeoxyadenosine on natural killer (NK)  dell mediated cytotoxicity. Purine and Pirimidine Metabolism in Man  VII, part A  Pages 69-73.
2-Ozes ON, Reiter Z,Klein SB, Blatt LM, and Taylor MW. 1992. A comparison of interferon con 1 with natural  recombinant interferon alphas: antiviral, antiproliferative and natural killer inducing activities.    J. Interferon Res. 12: 55-59.

3-Reiter Z,Ozes ON, Blatt LM, and Taylor MW. 1992. Cytokine and natural killer regulation of a hairy cell leukemia-like cell line. The role of interferon alpha and interleukin 2.  J. Immunotherapy. 11, 40-49.

4-Reiter Z, Ozes ON, Blatt LM and Taylor MW. 1992. A dual antitumor  effect of a combination of interferon alpha or interleukin 2 and 5-florouracil on natural killer cell-mediated cytotoxicity.  Clinical Immunology and Immunopathology 62, 103-111.

5-Reiter Z, Ozes ON, Blatt LM, Sturzl M, and Taylor MW.1992. A possible role  for interferon alpha and activated natural killer cells in  remission of AIDS-related Kaposi Sarcoma: In vitro studies.J. Acquired Immune Deficiency Syndrome. 5: 469-476.

6-Ozes ON and Taylor MW. 1993. Reversal of IFN gamma resistant  phenotype by poly I:C. Possible involvement of double-stranded RNA dependent kinase in IFN gamma mediated induction of the indolamine 2,3-dioxygenase (IDO) gene.  Journal of Interferon Research13, 283-288.

7-Ozes ON, Klein SB, Reiter Z and Taylor MW. 1993. An interferon resistant variant of the hairy cell leukemia like cell line, Eskol. Biochemical and immunological characterization. Leukemia Res. 17, 983-990.

8.Reiter Z, Tomson S, Ozes ON and Taylor MW. 1993.  Combination treatment of 2-chloroadenosine and type I interferons on hairy cell leukemia-like cells. Cytotoxic effect and MHC-unrestricted killer cell regulation.  Blood 81,1699-1708.

9.Ozes ON and Taylor MW. 1994.  Reversal of IFN gamma resistant phenotype by poly I:C. Possible involvement of Interferon  responsive factor 1 (IRF1) in IFN gamma mediated induction of the indolamine 2,3-dioxygenase (IDO) gene.
Journal of Interferon  Research   14, 25-32.

10.Hu CJ, Ozes ON, Klein SB, Blatt LM and Taylor MW. 1995.  Comparison of the in vitro host range of recombinant met-interferon-con1, interferon alpha2a, and interferon beta. J. Interferon  and Cytokine Research 15, 231-324.

11.Ozes ON,Mayo LD, Gustin, J.A., Pfeiffer, L.M. and Donner, D.B. 1999.  NF-kB activation by tumor necrosis factor requires the Akt serine-threonine kinase.  Nature 401, 82-85.

12.Lawless  VA, Zhang SS, Ozes ON, Bruns HA, Oldham I, Hoey T, Grusby MJ and Kaplan MH. 2000.  Stat4  regulates multiple components of IFN-gamma –inducing signaling pathways. J of Immunology 15;165(12):6803-6808.

13.  Wu, L.W., Mayo, L., Dunbar, J.D., Kessler, K.M, Ozes ON, Warren, R.S., and Donner, D.B. 2000.  VRAP is an adaptor protein that binds KDR,   a receptor for vascular endothelial cell growth factor.   J.Biol.Chem.  275, 6059-6062.

14. Guo,Wu, L-W., Dunbar, Ozes ON,Mayo LD, Kessler K.M., Gustin, J.A., Baerwald, M.R.,Jaffe, E.A., Warren, R.S. and Donner, D.B.  2000. Tumor necrosis factor employs a protein tyrosine phosphatase to inhibit activation of KDR and VEGF-induced  endothelial cell proliferation.   J. Biol. Chem. 276,11216-11221.

15. Ozes ON, Akca H,Mayo LD,Gustin JA, Maehama T,Dixon JE, and  Donner DB. 2001.  A phosphatidylinositol3-kinase/AKT/mTOR mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate –1. Proc Natl Acad Sci USA Apr 10:98 (8):4640-4645.

16.Keser I, Kayisli OG, Yesilipek A, Ozes ON, Luleci G. 2001. Hb Antalya (codons 3-5 (leu-Thr-Pro---Ser-Asp-Ser): a new unstable variant leading to chronic microcytic anemia and high HbA2. Hemoglobin.25(4):369-373.

17. İmir NG ve Özeş ON. 2002. IFN--mediated transcriptional induction of the IDO (indoleamine2,3-dioxygenase) gene requires activity of p68/PKR protein kinase. Turkish .J.Med Sci. 2002. 32:195-199.

18. İmir NG ve Özeş ON.2002. Investigation on antiproliferative effect of IFN- and 5-FU and hydroxyurea on human burkit lymphoma and erythroblastic leukemia cell lines. Turkish .J.of Cancer. 2002.32:12-19.

19.Akça H and Ozes ON. 2002. Anti-tumor effects of TNF- and 5-FU and their combinations on cervical carcinoma cell lines. Turkish J.of Med.Sci. 32:127-132.

20. Akca H, Yenisoy S, Yanikoglu A, Ozes ON. 2002. Tumor necrosis factor alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by  insulin in ME180S cells.
Clin Chem Lab Med .Aug:40(8):764-768.

21.Akca H, Yenisoy S, Yanikoglu A, Ozes ON. 2003. Suppression of Tumor Necrosis Factor-alpha-mediated apoptosis by EGF in TNF-alpha sensitive human cervical carcinoma cell line.  Growth Factors.  Mar;21(1)31-39.

22-Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo L, Li Q, Guzman JR, Korgaonkar CK, Donner DB. 2004. Cell type specific expression of  the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/AKT signaling to NF-kB activation. J.Biol Chem. 16:279(3):1615-1620.

23-Akca H, Ozes ON. 2003.  Epidermal growth factor suppresses interferon-induced accumulation of p53 and p21 by using protein kinase C. Scad J Clin Lab Invest.. 63(7-8):505-512.

24-Gustin JA, Pincheira R, Mayo LD, Ozes ON, Kessler KM, Baerwald CK, Donner DB. 2004. Tumor Necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. Am J Physiol Cell Physiol. 286(3):547-555.

25.Ozlem Guzeloglu Kayisli, Ibarahim Keser, Duran Canatan, Ahter Sanlioglu, Osman Nidai Ozes, Guven Luleci. 2004.  Identification of  a novel frameshift mutation [Codon 3 (+T)] in  a Turkish patient with b-thalassemia intermedia. Turkish J Med Sci. 35:175-177.

26.Ismail Turker Koksal, Ercument Dirice, Duygu Yasar, Ahter D.Sanlioglu, Akif Ciftcioglu, Kemal H.Gulkesen, Nidai O.Ozes, Mehmet Baykara, Guven Luleci, Salih Sanlioglu. 2004.  The assessment of PTEN tumor suppressor gene in combination with gleason scoring and serum PSA to evaluate progression of prostate carcinoma. Urologic Oncology Seminars and Original Investigations. 2004. 22:307-312.

27- Sibel Berker Karauzum, Duygu Yasar,Nilufer Imir, Ercument Dirice,  Guven Luleci , and Osman Nidai Ozes. 2007. Lack of BCL-2 confers Interferon-alpha sensitivity to B-cell lymphomas. Growth Factors.  Apr;25(2):94-100

28. Pincheira R, Castro AF, Ozes ON, Idumalla PS, Donner DB. 2008.  Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity.
J Immunol.. 15;181(2):1288-98.

Osman N.Ozes, Sarah Stevens, Tony Wang, Tim Tran, Lawrence M.Blatt. Preclinical Activity of Pirfenidone(5-Methyl-1-Phenyl-2[1H]-Pyridone)in cell-based model of Nonalcoholic Steatohepatitis. AASLD  Meeting, 2003, BOSTON, MA.

Osman N.Ozes, Tim Tran, Tony Wang, Sarah Stevens, Scott Seiwert,  Lawrence M.Blatt. Effect of Interferon-gamma 1b in Cellular Models of Lung Fibrosis: Implications for the treatment of Idiopathic Pulmonary Fibrosis. CHEST Meeting, 2004, SEATTLE,  WA.

Osman N.Ozes, Tony Wang, Lawrence M.Blatt,  Scott Seiwert. Interferon--1b Inhibits Interleukin-4(IL-4)up regulation in activated T-Cells and IL-4-induced Collagen Synthesis in Cellular Model of Fibrosis. ATS 2005, SAN DIEGO, CA.

Osman N.Ozes Interferon--1b Inhibits IL-4, ET-1,and TGF1-Induced Up-regulation of Type I Collagen in Cellular Models of Lung Fibrosis. CHEST Meeting, 2005, MONTREAL, CANADA.

Osman N.Ozes,  Sarah Stevens, Scott Seiwert,  Lawrence M.Blatt. Pirfenidone Inhibits Transforming Growth Factor beta-induced expression of b-JUN and prolongs Tumor Necrosis Factor--induction of cJUN:Implications for the treatment of Idiopathic Pulmonary Fibrosis. ATS Meeting, 2006, SAN DIEGO, CA.

Osman N.Ozes, Jena Derrick, Sarah K. Stevens, Milton Taylor, Tsukahara Takuma,   Lawrence M.Blatt.
Pirfenidone Does not Antagonize IFN--1b-induced signaling and gene induction: Implications for the treatment of Idiopathic Pulmonary Fibrosis. ATS Meeting, 2006, SAN DIEGO,CA.

Sarah K.Stevens, Lawrence M.Blatt, Osman N.Ozes Pirfenidone attenuates proinflammatory cytokine production in lipopolysaccaride-activated THP1 Cells Co-culture with Transforming Growth Factor -stimulated HFL1 ATS Meeting, 2006, SAN DIEGO,CA.
Osman N.Ozes Identification of the molecular target of Pirfenidone. CHEST Meeting, 2006, SALTLAKE CITY, UT.

Osman N.Ozes The Effect of Pirfenidone and Interferon-1b in Cellular Models of TGF-mediated gene induction. CHEST Meeting, 2006, SALTLAKE CITY, UT.

Osman N.Ozes, Lawrence M.Blatt Development of a high-throughput collagen assay using a cellular model of idiopathic pulmonary fibrosis. CHEST Meeting, 2006, SALTLAKE CITY, UT.

Sarah K.Stevens, Lawrence M.Blatt, Osman N.Ozes Pirfenidone in Combination with Interferon gamma-1b Inhibits Osteopontin-Induced Alveolar Epithelial Cell Proliferation and Activation of Mitogen-Activated Protein Kinases CHEST Meeting, 2006, SALTLAKE CITY, UT.

Roderick  J. Phillips,  Lawrence M.Blatt, Osman N.Ozes Pirfenidone and Interferon Gamma-1b Inhibit the Pro-Fibrotic Effects of Osteopontin CHEST Meeting, 2006, SALTLAKE CITY, UT.

Osman N.Ozes, Sarah K.Stevens, Jena Derrick, Lawrence M.Blatt. Pirfenidone enhances the inhibitory effects of Interferon-inducible T-cell alpha chemo attractant against belomycin-induced pulmonary fibrosis. ATS Meeting, May 2007, SAN FRANSISCO, CA.

Osman N.Ozes, Sarah K.Stevens, Jena Derrick, Lawrence M.Blatt. The combination of pirfenidone and interferon-g-1b results in additive suppression of bleomycin-induced pulmonary fibrosis. ATS Meeting, May 2007, SAN FRANSISCO, CA.

Maisoun Sulfab, Lawrence M.Blat, Osman N.Ozes Pirfenidone and interferon-gamma 1b inhibit TGF-induced epithelial to mesenchymal transition in alveolar epithelial cells and differentiation of human lung fibroblasts. ATS Meeting, May 2007, SAN FRANSISCO, CA.

Maisoun Sulfab, Lawrence M.Blat, Osman N.Ozes The effects of pirfenidone and IFN-inducible T-cell alpha chemo attractant on transforming growth factor beta–mediated synthesis of extra cellular matrix proteins in endothelial cells.
ATS Meeting, May 2007, SAN FRANSISCO, CA.

Sarah K.Stevens, Lawrence M.Blat, Osman N.Ozes Interferon-1b reduces the basal and TGF--induced integrin receptor levels in HFL1 cells ATS Meeting, May 2007, SAN FRANSISCO, CA.

Sarah K.Stevens, Lawrence M.Blat, Osman N.Ozes Effects of pirfenidone and Interferon-1b on the basal and bleomycin-induced cytokines in the mouse. ATS Meeting, May 2007, SAN FRANSISCO, CA.

Zvi Reiter, Osman N Ozes, Sue Tomson, Lawrence M.Blatt, and Milton W. Taylor. A dual anti-tumor effect of a combination of interferon a- and 5-flurouracil or 2-chlorodeoxyadenosine on natural killer (NK) cell mediated cytotoxicity. Purine and primidine Metabolism in Man VII, part A. 69-73.
Osman Nidai Ozes, Hakan Akca, Jason A Gustin, Lindsey Mayo, Roxan Pinchera, Chandrahekhar K. Korgaonkar and David B Donner. Tumor Necrosis factor a-receptor signaling through the AKT kinase. Cell Signaling and Vascular İnflammation.13-22.2005. Human Press Inc.,999 Riverwiev Drive., Suite 208 Totowa, New Jersey.
Ulusal hakemli dergilerde yayınlanan makaleler
Hakan Akça, Atila Yanıkoğlu, Osman Nidai Özeş. Hücre içi p53 seviyesinin Epidermal Büyüme Faktörü Tarafından Kontrolü. Türk Hematoloji-Onkoloji Dergisi, 12 (2) 61-66, 2002.

Ayşegül Nasırcılar, Osman Nidai Özeş, Şeyda Karaveli. Malign Meme Neoplasmlarında p53 ün İmmunohistokimyasal Tespiti. Sağlık Bilimleri Araştırma Dergisi, 11 (24), 225-234, 2001.

O.Nidai Özeş, Erol Aksöz. Farklı Karbon Kaynaklarının Aspergillus niger’in Poligalakturonaz Enzim Üretimine Etkileri. DOĞA, 13, 3, 162-170. 1989.

Sibel Berker Karaüzüm, Güven Lüleci, Nidai Özeş, Ayşegül Nasırcılar, Tekinalp Gelen, Şeyda Karaveli, Mehmet Öğüş.
Meme karsinomlarında kurulan doku kültürlerinde sitogenetik ve moleküler genetic çalışmalar.
13. Ulusal Kanser Kongresi, 27 Nisan 1 Mayıs 1999. Belek Antalya.

Hakan Akça, Osman N. Özeş, Şeyda Karaveli.
P68 kinaz enziminin tumor baskılayıcı ve interferon gama sinyal iletim mekanizmasındaki rolünün araştırılması.
13. Ulusal Kanser Kongresi, 27 Nisan 1 Mayıs 1999. Belek Antalya.

Hakan Akça, Osman N. Özeş, Ayşegül Nasırcılar, Nilüfer İmir, Sibel Karaüzüm, Tekinalp Gelen, Mehmet Öğüş, Şeyda Karaveli.
P68 kinaz enziminin tumor baskılayıcı rolünün araştırılması.
13. Ulusal Kanser Kongresi, 27 Nisan 1 Mayıs 1999. Belek Antalya.
Nilüfer Gülmen, O.Nidai Özeş.
İnterferon alfanın 5-FU ve H.Üre ile kombinasyonlarının Lökemik hücreler üzerine etkisi.
12. Ulusal Kanser Kongresi, 23-26 Nisan 1997. Belek Antalya.

Hakan Akça, O.Nidai Özeş.
Servikal karsinoma hücrelerinde tumor nekrosis faktör beta tarafından apoptosisin indüksiyonu.
12. Ulusal Kanser Kongresi, 23-26 Nisan 1997. Belek Antalya.

O.Nidai Özeş.
Çeşitli lösemik hücrelerde interferon alfa tarafından apoptosisin indüksiyonu.
12. Ulusal Kanser Kongresi, 23-26 Nisan 1997. Belek Antalya.

O.Nidai Özeş, Erol Aksöz.
Aspergillus flavus poligalakturonaz sentez ve aktivitesini etkileyen bazı faktörler.
9. Ulusal Biyoloji Kongresi, 21-23 Eylül 1988. Sivas.

Nilüfer Aksöz, Erol Aksöz, Nilüfer Cihangir, O.Nidai Özeş.
Bazı fungal kaynakların gibberellik asit verimleri yönünden karşılaştırılması.
1.Ulusal Biyoteknoloji Sempozyumu, 5-7 Eylül 1988. Ankara.

O.Nidai Özeş, Erol Aksöz.
Aspergillus flavus poligalakturonazı üzerinde çalışmalar.
1.Ulusal Biyoteknoloji Sempozyumu, 5-7 Eylül 1988. Ankara.

IDO (Indolamine 2,3- deoxygenase) enziminin transkripsiyonel indüksiyon mekanizmasının araştırılması, TÜBİTAK, TBAG-1347.
p68 Kinaz ve IRF-1 (Interferon Regulatory Factor-1) in tumor baskilayici ve Interferon gama sinyal iletim mekanizmasindaki rolu, Akdeniz Üniversitesi Bilimsel Araştırma Projeleri Yönetim Birimi, 96.01.0103.08.
p68 Kinaz ve IRF-1 (Interferon Regulatory Factor-1) in tumor baskilayici ve Interferon gama sinyal iletim mekanizmasindaki rolu, TUBITAK, TBAG-1449.

Akdeniz Üniversitesi Biyoloji Bölümü Moleküler Biyoloji ABD Başkanı 1996-1997